Search results for "Antibiotics"
Drug shortages drag on
Almost all hospital pharmacists reported facing drug shortages in a recent survey, but there are some available solutions, one expert says.
https://acphospitalist.acponline.org/archives/2023/10/04/free/drug-shortages-drag-on.htm
4 Oct 2023
Intermittent multidrug IV therapy potentially useful in refractory Mycobacterium abscessus pulmonary disease
In a small study of 36 patients in South Korea, 62% and 12% of those with M. abscessus disease and 80% and 60% of those with M. massiliense disease had at least one negative culture and culture conversion, respectively.
https://acphospitalist.acponline.org/archives/2023/09/13/intermittent-multidrug-iv-therapy-potentially-useful-in-refractory-mycobacterium-abscessus-pulmonary-disease.htm
13 Sep 2023
Guidelines on resistant gram-negatives
Hospitalists are some of the best antibiotic stewards, according to the lead author of recent guidance that aims to help them manage tricky infections.
https://acphospitalist.acponline.org/archives/2023/09/06/free/guidelines-on-resistant-gram-negatives.htm
6 Sep 2023
First-line antibiotic options for CAP on the wards show similar mortality rates
A large retrospective study of patients with community-acquired pneumonia (CAP) found similar inpatient mortality with a beta-lactam plus a macrolide, a beta-lactam plus doxycycline, or a respiratory fluoroquinolone. A beta-lactam alone appeared less effective.
https://acphospitalist.acponline.org/archives/2023/08/23/first-line-antibiotic-options-for-cap-on-the-wards-show-similar-mortality-rates.htm
23 Aug 2023
Catching C. diff cases, not colonization
Researchers have found innovative ways to improve hospital systems for diagnosing Clostridioides difficile.
https://acphospitalist.acponline.org/archives/2023/08/16/catching-c-diff-cases-not-colonization.htm
16 Aug 2023
Hospital antibiograms may not be accurate for selecting initial empiric therapy
A retrospective cohort study of Veterans Health Administration facilities found that facility-level antibiograms had limited utility in predicting individual resistance for Escherichia coli and Klebsiella species in individual patients.
https://acphospitalist.acponline.org/archives/2023/08/16/hospital-antibiograms-may-not-be-accurate-for-selecting-initial-empiric-therapy.htm
16 Aug 2023
Time to antibiotics matters for septic shock, not so much for sepsis without shock
Every hour that antibiotics were delayed was associated with higher mortality from septic shock, but patients with sepsis and no shock only had elevated risk of death if their antibiotics were not administered within six hours, according to a new analysis.
https://acphospitalist.acponline.org/archives/2023/08/09/time-to-antibiotics-matters-for-septic-shock-not-so-much-for-sepsis-without-shock.htm
9 Aug 2023
Cases from the University of Nevada, Las Vegas
A group of cases involving lytic lesions.
https://acphospitalist.acponline.org/archives/2023/08/09/free/a-group-of-cases-involving-lytic-lesions.htm
9 Aug 2023
IDSA updates guidance on managing drug-resistant, gram-negative infections
New treatment recommendations from the Infectious Diseases Society of America (IDSA) dealt with resistant strains of Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia.
https://acphospitalist.acponline.org/archives/2023/07/26/idsa-updates-guidance-on-managing-drug-resistant-gram-negative-infections.htm
26 Jul 2023
Long-term doxycycline may reduce exacerbations for some COPD patients
A randomized trial in the U.K. found that 12 months of doxycycline did not improve chronic obstructive pulmonary disease (COPD) exacerbations overall versus placebo but may have reduced rates in patients with severe disease or lower blood eosinophil counts.
https://acphospitalist.acponline.org/archives/2023/07/26/long-term-doxycycline-may-reduce-exacerbations-for-some-copd-patients.htm
26 Jul 2023