Search results for "Antibiotics"
Less definitely more in antibiotics
Review some common inpatient conditions that can be safely treated with shorter durations of antibiotics, reducing adverse events and costs.
https://acphospitalist.acponline.org/archives/2023/05/17/less-definitely-more-in-antibiotics.htm
17 May 2023
Prophylactic antibiotics did not improve survival in severe alcohol-related hepatitis
A double-blind randomized trial found no significant differences in all-cause mortality between hospitalized participants who received amoxicillin-clavulanate in addition to prednisolone versus prednisolone alone.
https://acphospitalist.acponline.org/archives/2023/05/17/prophylactic-antibiotics-did-not-improve-survival-in-severe-alcohol-related-hepatitis.htm
17 May 2023
Recommendations on preventing surgical-site infections updated
The latest recommendations from the Society for Healthcare Epidemiology of America lowered the recommended postoperative target glucose level from less than 180 mg/dL to between 110 and 150 mg/dL, among other changes.
https://acphospitalist.acponline.org/archives/2023/05/10/recommendations-on-preventing-surgical-site-infections-updated.htm
10 May 2023
Procalcitonin algorithm reduced antibiotic use in COVID-19 inpatients
A Dutch intervention used procalcitonin levels in inpatients with COVID-19 to guide antibiotic use, with an algorithm discouraging prescriptions if levels were less than 0.25 ng/mL and recommending antibiotics for patients with levels above 0.5 ng/mL.
https://acphospitalist.acponline.org/archives/2023/05/03/free/procalcitonin-algorithm-reduced-antibiotic-use-in-covid-19-inpatients.htm
3 May 2023
Antibiotic regimens differ in associated risk of AKI in critically ill patients
Vancomycin and piperacillin/tazobactam were associated with a higher risk of acute kidney injury (AKI) than either vancomycin and cefepime or vancomycin and meropenem in ICU patients, particularly at longer durations and in those with normal kidney function on admission.
https://acphospitalist.acponline.org/archives/2023/04/19/antibiotic-regimens-differ-in-associated-risk-of-aki-in-critically-ill-patients.htm
19 Apr 2023
Few low-risk inpatients with CAP switched from IV to oral therapy
Patients hospitalized with community-acquired pneumonia (CAP) who transitioned from IV to oral antibiotics by day 3 had shorter length of stay and lower hospitalization cost than those who did not, with no increase in 14-day mortality or ICU admission, a retrospective study found.
https://acphospitalist.acponline.org/archives/2023/04/12/few-low-risk-inpatients-with-cap-switched-from-iv-to-oral-therapy.htm
12 Apr 2023
Inpatient oral penicillin challenge more likely in certain low-risk patients
An inpatient penicillin allergy program showed that patients were more likely to proceed from assessment to oral challenge if they had a low-risk phenotype, had an indication for beta-lactam antibiotic therapy, and were medically stable.
https://acphospitalist.acponline.org/archives/2023/03/29/inpatient-oral-penicillin-challenge-more-likely-in-certain-low-risk-patients.htm
29 Mar 2023
Early hydrocortisone therapy reduced 28-day mortality in ICU patients with severe CAP
A phase 3 double-blind trial in France randomly assigned adults who had been admitted to the ICU with community-acquired pneumonia (CAP) to receive IV hydrocortisone or placebo for eight to 14 days.
https://acphospitalist.acponline.org/archives/2023/03/29/early-hydrocortisone-therapy-reduced-28-day-mortality-in-icu-patients-with-severe-cap-french-trial-finds.htm
29 Mar 2023
Learning on the late shift
Training programs and hospitalists are working to make night coverage more educational.
https://acphospitalist.acponline.org/archives/2023/03/22/free/learning-on-the-late-shift.htm
22 Mar 2023
Transitioning to oral therapy for infective endocarditis supported by real-world study
A retrospective study at three L.A. hospitals found similar rates of clinical success at 90 days in patients who received entirely IV therapy or were transitioned to oral antibiotics for infective endocarditis, and adverse events were less common in the latter group.
https://acphospitalist.acponline.org/archives/2023/03/15/transitioning-to-oral-therapy-for-infective-endocarditis-supported-by-real-world-study.htm
15 Mar 2023