Based on reports of cerebral venous sinus thrombosis with the Johnson & Johnson (Janssen) COVID-19 vaccine, federal officials recommended a pause in its use, which will be reconsidered on April 23.
Most U.S. hospitals provided patients with similar guidance on isolation, but their criteria for discharge varied, leading the study authors to call for more research in this area. An Italian study found high incidence of hospital-acquired infections among COVID-19 patients in ICUs.
A randomized trial of hospital at home found no difference in the proportion of patients who had died or were living at home at six months, although participants who had received care at home were less likely to be in long-term residential care than those who had been hospitalized.
In a pre- and postintervention quality improvement study, physicians at three academic hospitals in California were trained to use time-limited trials of interventions in communication and care planning with families and surrogate decision makers of critically ill ICU patients.
A Dutch study found that opioid use in the ICU increased the daily risk of delirium by 45% in a dose-dependent manner and that this increased risk was independent of the degree of pain present.