Search results for "Antibiotics"
Longer antibiotic delay intervals associated with hospital mortality in patients with suspected sepsis
While both time from ED triage to antibiotic order and time from antibiotic order to infusion were associated with increased hospital mortality, this was true only for longer delays, indicating that a one-hour antibiotic administration target may be too aggressive, study authors said.
https://acphospitalist.acponline.org/weekly/archives/2021/02/24/5.htm
24 Feb 2021
Short-course antibiotics in low-risk MSSA bacteremia did not increase mortality risk
Patients receiving six to 10 days of antibiotic therapy for uncomplicated methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia had similar 90-day mortality and relapse rates compared to those who got 10 to 16 days of therapy in a retrospective Danish study.
https://acphospitalist.acponline.org/weekly/archives/2021/03/10/3.htm
10 Mar 2021
Antibiotics with extended anaerobic coverage didn't improve outcomes in aspiration pneumonia
Patients with aspiration pneumonia who received extended anaerobic coverage had no reduction in mortality risk and a significantly higher risk of Clostridioides difficile than those prescribed limited anaerobic coverage.
https://acphospitalist.acponline.org/archives/2024/02/28/antibiotics-with-extended-anaerobic-coverage-didnt-improve-outcomes-in-aspiration-pneumonia.htm
28 Feb 2024
New combo antibiotic shows success against complicated urinary tract infections
Microbiologic and clinical recovery occurred in 70.6% of hospitalized patients randomized to an investigational beta-lactam and beta-lactamase inhibitor combination for urinary tract infection compared to 58% of patients given meropenem, an industry-funded trial found.
https://acphospitalist.acponline.org/archives/2024/02/21/new-combo-antibiotic-shows-success-against-complicated-urinary-tract-infections.htm
21 Feb 2024
Hospital-level antibiotic use associated with rates of hospital-onset C. diff
Hospitals that significantly reduced use of all antibiotics, or specifically fluoroquinolones or third- and fourth-generation cephalosporins, achieved decreases in hospital-onset Clostridioides difficile, the retrospective study showed.
https://acphospitalist.acponline.org/weekly/archives/2019/03/13/3.htm
13 Mar 2019
Hospitals that steward antibiotics well share common factors
Hospitals where pharmacists reported feeling that they are respected by their hospitalist colleagues and considered valuable team members were less likely to overuse antibiotics, a small survey study of antibiotic stewardship programs found.
https://acphospitalist.acponline.org/archives/2023/12/20/hospitals-that-steward-antibiotics-well-share-common-factors.htm
20 Dec 2023
Algorithms predicted antibiotic resistance profiles of inpatients' bacterial infections
Machine learning models applied to medical records of hospitalized patients achieved high-accuracy predictions in a recent study and “should be seriously considered by clinicians to aid correct empiric therapy,” the authors said.
https://acphospitalist.acponline.org/weekly/archives/2020/10/28/4.htm
28 Oct 2020
CMS sepsis measure associated with increases in antibiotic use
Use of broad-spectrum antibiotics, especially in sepsis patients, went up after SEP-1 was implemented, but rates of Clostridioides difficile infection decreased.
https://acphospitalist.acponline.org/weekly/archives/2020/09/02/5.htm
2 Sep 2020
Less definitely more in antibiotics
Review some common inpatient conditions that can be safely treated with shorter durations of antibiotics, reducing adverse events and costs.
https://acphospitalist.acponline.org/archives/2023/05/17/less-definitely-more-in-antibiotics.htm
17 May 2023
Individualized short-course antibiotics noninferior to usual care for VAP
In a randomized open-label trial, 41% of ICU patients with ventilator-associated pneumonia (VAP) who received antibiotics for seven days or less died or had pneumonia recurrence at 60 days versus 44% of those who received usual care.
https://acphospitalist.acponline.org/archives/2024/01/31/individualized-short-course-antibiotics-noninferior-to-usual-care-for-vap.htm
31 Jan 2024